There is despair, and then there is the pit of despair, as 50 Cent pinpoints the reason for Nas' decline - he's too worried about all this booklearning:
A book? Can you even imagine such a weird thing to be doing?
If having some interest in your world moves you "conceptually" away from your audience, that would seem to be an audience you're better without. Happily for 50 Cent, we can comfortably conclude he's not about to try and raise himself above whatever level of ignorance he has so far managed to achieve.